Blocks pain transmission by depleting substance P, your body’s pain messenger
Works directly at the source to help relieve osteoarthritis pain
Suitable for everyday use for chronic osteoarthritis
Zostrix contains capsaicin which is the purified extracted alkaloid from red chilli peppers (capsicums); the substance that makes chilli peppers hot. Capsaicin has been shown to help relieve osteoarthritis pain by reducing levels of substance P(1,2,3,4), the body’s pain messenger which is found at the nerve endings and is involved in transmitting pain signals to the brain.
Applying Zostrix may cause a mild to moderate localised burning sensation initially which usually decreases or disappears with time and regular use. This is quite normal, particularly during the early stages of treatment, and is a sign that the cream is working.
Pain relief is not instantaneous after application as it is the cumulative depletion of substance P following continued use over a period of 4+ weeks that gradually brings the full effect.
Unlike other treatments such as topical NSAID’s (non-steroidal anti-inflammatory drugs) which should not be used for more than 3 weeks consecutively, Zostrix is suitable for everyday use to help relieve chronic osteoarthritis pain.
In a clinical trial, Zostrix reduced osteoarthritis pain by up to 50% when used regularly as the sole treatment over a 12 week period, and 80% of test subjects experienced pain relief.1
Pain severity VAS. A double-blind, randomised 12-week comparison of Zostrix q.i.d. monotherapy (n=57) or placebo vehicle (n=56) in patients with OA.1 Adapted from Altman RD et al.1
In a separate study when used in combination with other medications, Zostrix provided up to 33% more pain relief in addition to the pain relief for osteoarthritis achieved with oral NSAID’s or Paracetamol alone.2